A round-up of the latest transfer speculation involving Chelsea and QPR…Speculation continues over the future of Charlie Austin after QPR rejected a £12m bid from Leicester.Rangers want £15m for the striker and Leicester’s bid was the first offer or approach they have had for Austin despite numerous reports of them receiving both.Newcastle were previously tipped to capture Austin but no move has materialised. However, the north-east media still insist Magpies boss Steve McClaren is in the running to sign him.The Northern Echo say Newcastle are ready to battle for Austin’s signing but the newspaper believes he would rather stay in London and join West Ham.Newcastle have been linked with Austin but have not made an approachThe Shields Gazette, which suggests Newcastle would be prepared to pay Austin big wages, believe the club are having to play a waiting game because he is stalling to see if Chelsea come in for him.Again the suggestion is that Austin, 25, would rather remain in the capital and join the Blues or West Ham.The Newcastle Evening Chronicle say Austin is McClaren’s top transfer target and the Magpies are ready to step up their apparent interest following Leicester’s bid.The Leicester Mercury reports that Leicester are expected to increase their offer in an attempt to sign Austin.Meanwhile, Radamel Falcao accepted a 50% pay cut to join Chelsea from Monaco on a season-long loan, according to the Daily Mail.The Daily Express claim Tottenham are set to beat Chelsea to the signing of Anderlecht striker Aleksandar Mitrovic.Italian media reports have linked Spurs with the Serbian and the Express say Chelsea also want him.And Spanish newspaper Super Deporte has reported that Chelsea boss Jose Mourinho has asked agent Jorge Mendes to find a new club for Juan Cuadrado – just six months after the Colombian’s move to Stamford Bridge. Valencia are said to be interested.Follow West London Sport on TwitterFind us on Facebook
Poor defending from Fulham saw them go a goal down four minutes before the break.Despite having the better of the chances in the first half, the Whites were caught out when Aron Gunnarsson escaped the attentions of Richard Stearman and, with the outside of his right boot, clipped in a cross for Lex Immers, who was left totally unmarked to head in.Cardiff almost doubled their lead immediately afterwards as Sean Morrison’s header came back off the post.Fulham had had the better of the first half chances prior to the goal, with Emerson Hyndman and Ross McCormack both denied by Cardiff keeper David Marshall.Slavisa Jokanovic’s side, chasing a third league win in seven days, looked bright going forward and Moussa Dembele skied an early shot from the edge of the box.Cardiff, who need the points to keep in touching distance of the play-off places, responded with headers from Gunnarsson and Bruno Ecuele-Manga, which did not unduly threaten the home goal.Hyndman, who replaced the injured Tom Cairney in the starting line-up, showed the energy he can bring to the side when he intercepted a pass on the halfway line, strode forward 40 yards and then getting a shot away which Marshall palmed behind.Marshall was also equal to McCormack’s curling free-kick, but Fulham were left to rue lapses of concentration at the back when Cardiff went in front.Fulham: Bettinelli; Stearman, Madl, Amorebieta, Garbutt; Tunnicliffe, Parker, Ince, Hyndman; McCormack, Dembele.Subs: Lonergan, Fredericks, Burn, Baird, Christensen, Woodrow, Smith.Cardiff: Marshall; Peltier, Morrison; Ecuele-Manga, Malone; Noone, Gunnarsson, Ralls, Whittingham; Lawrence, Immers. Subs: Moore, Fabio, Connolly, Dikgacoi, O’Keefe, Zohore, Saadi.Follow West London Sport on TwitterFind us on Facebook
Laymen appreciate scientists who can express complex concepts in everyday terms. Here’s a good example from the Wistar Institute:Around the home, regularly used tools are generally kept close at hand: a can opener in a kitchen drawer, a broom in the hall closet. Less frequently used tools are more likely to be stored in less accessible locations, out of immediate reach, perhaps in the basement or garage. And hazardous tools might even be kept under lock and key. Similarly, the human genome has developed a set of sophisticated mechanisms for keeping selected genes readily available for use while other genes are kept securely stored away for long periods of time, sometimes forever. Candidate genes for such long-term storage include those required only for early development and proliferation, potentially dangerous genes that could well trigger cancers and other disorders should they be reactivated later in life.The article discusses how researchers at Wistar Institute found a two-molecule complex that governs how the chromatin that packages DNA will become either loosely organized or tightly condensed. Some unknown switching mechanism determines how ASF1 will bind to one of two similar molecules, HIRA and CAF1, that determine the degree of tight packing:An unanticipated observation from the study centers on the region of association between the two molecules in the complex. The researchers knew that one of the two molecules in the complex, called ASF1, associated with a particular molecular partner, HIRA, when directing assembly of the more condensed form of chromatin. But it could also associate with a different partner, called CAF1, to shepherd assembly of the less condensed form of chromatin. On closer study, the scientists discovered that HIRA and CAF1 have nearly identical structural motifs in the regions of interaction with ASF1. This means that ASF1 can bind to one or the other molecular partner, but not to both. In other words, the interaction is mutually exclusive: A kind of decision is made by ASF1 as to whether to guide the assembly process towards the more or less condensed forms of chromatin. What determines the choice? The relevant factors are unknown for now.However it works, it’s important: one researcher explained, “Appropriate packaging of the DNA in the cell nucleus is crucial for proper functioning of the cell and suppression of disease states, such as cancer.” The research has been published online in Nature Structural and Molecular Biology.11Tang et al., “Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly,” Nature Structural and Molecular Biology, Oct. 2006, published online: 17 September 2006; doi:10.1038/nsmb1147.Good work, by scientists operating on design principles (whether they realize it or not). There was no mention of evolution in the press release. It would would seem, also, that evolutionary theory would be useless in tracking down the factors that determine which binding takes place. You might not have realized that your genetic toolkit has power tools that are dangerous. Just like you would lock up hunting rifles in a secure cabinet, so that they won’t be used for the wrong purpose, your genetic system has controlled procedures for locking up its dangerous equipment. Most of the trillions of cells in your body get it right for decades, and even when there’s an accident, the body has other procedures for containing the damage. It is mind-boggling that all this goes on without our conscious knowledge, so that we can be conscious, and gain knowledge.(Visited 7 times, 1 visits today)FacebookTwitterPinterestSave分享0
Related Posts Cognitive Automation is the Immediate Future of… This month, two painful but impossible to ignore facts have emerged about mobile use by business. First, research from Forrester suggests IT support for business use of personal mobile devices has a big impact on enterprise collaboration, with fewer of the challenges that new technology like cloud computing present. Second, a new report from Gartner asserts that despite mobile IT support just beginning to really blossom, a full 80% of businesses will spend more than they need to on voice and data costs in the next five years. That dichotomy, the one between big expectations and overeager spending, is a paradigm that could cripple the sustainable growth of mobile in the enterprise. Mobile CollaborationThe new report by Forrester Research, Technology Populism Fuels Mobile Collaboration, tracks both how enterprises are using mobile now, and how increased assistance for it by employees can have tangible results for the level of collaboration that goes on. 82% of working adults have a personal mobile device. To not support their business use of it would be an enormous missed opportunity. According to Forrester, the key benefits are faster team work and decision making. The fact that mobile access to corporate data would be a booster is hardly a surprise, but backing it up with this kind of data should be a first step in goading management to commit to mobile in the enterprise. Widespread OverspendingAs something of a counterpoint to Forrester’s research, Gartner has issued a stern warning to enterprises: 80% of you will overspend on mobile services. Gartner predicts that in the next five years, at least 15% of the money for mobile devices and plans for voice and data will be unnecessarily spent. Particularly troublesome is the inefficient strategies companies have for reducing costs and negotiating contracts tailored to businesses, rather than piecemeal personal plans purchased on an enterprise scale. The combination of rising expectations for ROI plus the potential to overspend could very well cripple the support for mobile in the future, if enterprises aren’t careful. Image credit: James Cridland Tags:#enterprise#Trends steven walling 3 Areas of Your Business that Need Tech Now Massive Non-Desk Workforce is an Opportunity fo… IT + Project Management: A Love Affair
selena larson The Dos and Don’ts of Brand Awareness Videos YouTube announced a new way of filtering out annoying comments on videos. Starting this week, YouTube comments will be powered by Google+, Google’s social network.The video site is notorious for users who down-vote videos en masse or post vicious replies, so YouTube is taking action to provide higher-quality comments and conversations.YouTube declares that it’s making comments better by integrating Google+. It will prioritize comments from recognizable profiles, like the video creator or friends. Posted comments can be shared privately or in users’ Google+ circles, and additional moderating tools will give video creators the ability to block phrases or auto-approve comments. “The grand idea is to try and turn these one-off comments into conversations that you really care about,” said Matt McLernon, a spokesperson for YouTube.But There’s Another Agenda HereWhile this seems like an effort by YouTube to improve the user experience, it is also a thinly veiled attempt by Google to bring Google+ services to the mainstream. Google has already integrated its social network in most of its products with the hopes of increasing engagement, provoking annoyance among some users. YouTube will be one of Google’s largest platforms to force its users to sign up for a Google+ account.Google+ may be the web’s second-largest social network behind Facebook, but that could be due to the fact that almost everyone with a Gmail account has a Google+ account, too. Whether they’re using them or not is another story.YouTube users who don’t already have a Google+ account will have to sign up for one using a Gmail address in order to participate in page discussions and, eventually, to comment on videos.YouTube said that users can register with either a Google+ profile or page so they can still use anonymous usernames. “On the Google+ side, you enter as much information as you like,” McLernon said. “On the YouTube side you can use a Plus page, so if you want to be awesomeperson5000, you can do that.” YouTube claims that the majority of YouTube commenters are already Google+ users, so many people might not even notice a difference. But with over one billion monthly unique users, there is bound to be a significant amount of people that registered with alternative email addresses. The company is risking a user revolt by mandating all commenters be Google+ users, as many people are already unhappy that the service is being forced on them. YouTube will begin rolling out the changes on channel pages today, with the exclusive Google+ commenting and linking system due globally later this year.Image via BrianDHawkins on Flickr Related Posts Tags:#Google#YouTube Guide to Performing Bulk Email Verification Facebook is Becoming Less Personal and More Pro… A Comprehensive Guide to a Content Audit
India has been blessed with some of the greatest athletes the world has ever seen across a wide variety of sports. Cricket is arguably the most followed sport in the country ever since our dominance in field hockey faded away but even before that India had made its name in other sports like football and track and field.Before our independence in 1947, there were some athletes from India who made the country proud, especially at the Olympics. Hockey was one such sport which India dominated for over three decades, winning eight gold medals, the most by any country at the Summer Games.From 1928 to 1956, the Indian men’s hockey team remained unbeaten winning six gold medals in succession with a 30-0 unbeaten streak.Even before great sportspersons like Sunil Gavaskar, Kapil Dev, Sachin Tendulkar, Prakash Padukone and Milkha Singh made their names in their respective sports, India had some legendary athletes in its arsenal led by the greatest hockey player to walk on this planet – Dhyan Chand.So let’s rewind the clock and take a look at five legendary Indian athletes from the pre-independence era.Norman Pritchard (Track & Field)Born to British parents in Calcutta in 1877, Norman Pritchard was the first Indian athlete to win a medal at the Olympic Games.Representing India, Pritchard participated in the men’s 200 metres, 200 metres hurdles, 110 metres hurdles, 60 metres sprint and 100 metres sprint at the 1900 Summer Games in Paris.Pritchard won silver medals in 200 metres and 200 metres hurdles, thus, becoming the first Indian and first athlete representing an Asian nation to win an Olympic medal. He had made it to the final of 110 metres hurdles, but did not finish, and also participated in the 60m and 100m sprints, in which he failed to qualify for the finals.advertisementPritchard was also an equally talented football player and is credited with scoring the first hat-trick in an open football tournament in India, for Saint Xavier’s College against Sovabazar in July 1897.He was also the secretary of the Indian Football Association from 1900 to 1902 before moving to Great Britain in 1905. Pritchard then shifted base to the United States where he adopted the name ‘Norman Trevor’ and acted in silent films in Hollywood and also appeared in several Broadway shows.Mohammed Salim (Football)Mohammed Salim was one of the greatest footballers India has ever produced. Salim was born in Calcutta in 1904 and quickly gained a name in football first joining Bowbazar and then going on to play for the B team of Mohammedan Sporting Club.Legendary sports administrator Pankaj Gupta took notice of Salim’s talent and recruited him to play for his club Sporting Union where he spent five years from 1927-31.Salim then played for East Bengal Club in 1932 before joining Aryans Club a year later. But he returned to Mohammedan SC soon after and helped the club win the prestigious Calcutta Football League title five years in a row.In 1936 Salim became the first player from India to represent a European club as he was signed by Celtic FC after a trial he gave in bare feet and in front of 1000 club members.He made a debut for Celtic in a 5-1 victory against Galston and scored a goal through penalty. He stayed at the club for a season before heading back to Mohammedan SC as he was feeling home sick. Salim was also offered a professional contract to play in Germany but he declined that as well.Vijay Merchant (Cricket)Vijay Madhavji Merchant was a revered cricketer from India in the pre-independence era. Born in Bombay (now Mumbai) in 1911, Merchant was a fine right-handed batsman with a first-class average of over 71 having played 150 matches in which he amassed 13,470 runs with 45 hundreds, 11 of which were double tons.Merchant made his Test debut for India against England at the Gymkhana ground in Bombay (now Mumbai) in December, 1933. Merchant scored 23 and 30 as India lost the match by 9 wickets.Merchant loved to bat against England and in the two tours there he amassed over 4000 runs combined, which just goes to show how good he was against fast bowlers on seaming tracks. Merchant played a starring role in the Manchester Test in 1936 when he slammed 114 and added 203 runs with Mushtaq Ali (112) to help save the match as India trailed by 368 runs.Such was Merchant’s prowess with the bat that English cricketer C.B. Fry once said, “Let us paint him white and take him with us to Australia (for the Ashes) as an opener.”Throughout his career, Merchant played 10 Test matches and scored 859 runs at 47.72 with three hundreds and as many fifties. His life after retirement revolved around cricket administration, broadcasting and writing.advertisementRanjitshinghji (Cricket)The man who invented the famous leg glance and late cut, Maharaja Jam Saheb of Nawanag or Kumar Shri Ranjitsinhji, was probably the greatest batsman to have played cricket in the pre-independence era. He had an unorthodox in technique, had quick reflexes and he brought a new style to batting which completely revolutionised the game.Ranjitsinhji never played for India but inspired everybody back home to take up the sports across generations. He was the first Indian to play international cricket and represented England and Sussex.Ranjitsinhji made his Test debut for England against Australia in July 1896 and scored 62 and 154 not out at Manchester. From 1895 he exceeded 1000 runs in 10 successive seasons, passing 3000 in 1899 and 1900.From 1896 to 1902, Ranjitsinhji played 15 Test matches and scored 989 runs at an average of 44.95 with two hundreds and six half-centuries. He got out on a duck only two times in his career.Ranjitsinhji led Sussex for five years from 1899-1903 and his name became synonymous with the club. First-class cricket saw Ranjitsinhji score 24692 runs in 307 matches at an average of 56.37 with 72 hundreds along with that he also took 133 wickets.The Board of Control for Cricket in India (BCCI) named its oldest first-class cricket tournament – Ranji Trophy – in honour of Maharaja Ranjitsinhji. Ranji Trophy began in 1934 and is still India’s premier domestic tournament.Dhyan Chand (Hockey)He is the greatest hockey player ever, period!Unlike in other sports where people compare players from different era’s but still find it hard to pronounce one true champion, fortunately that is not the case with hockey.Ask any field hockey player from the current or past generations and they will have just one name in mind when it comes to the greatest of all time – Dhyan Chand.Born in Uttar Pradesh, Chand played a starring role when India completed a hat-trick of Olympic gold medals in 1928, 1932 and 1936 in field hockey during the nation’s most dominant phase in the sport.Known for his extraordinary goal-scoring feats and ball control, Chand scored over 400 international goals in his career. He was conferred the Padma Bhushan award after he retired from the Army with the rank of Major in 1956.Talks are ongoing for the Bharat Ratna, India’s highest civilian award, to be conferred upon Dhyan Chand, especially after cricket legend Sachin Tendulkar received the honour in 2013.Of all the matches that he played during his 22-year long career (1926-48), Dhyan Chand considers the 1933 Beighton Cup final between his home team Jhansi Heroes and Calcutta Customs as the best one.”If anybody asked me which was the best match that I played in, I will unhesitatingly say that it was the 1933 Beighton Cup final between Calcutta Customs and Jhansi Heroes. I had a team which was determined to do or die. It was a great match, full of thrills, and it was just opportunism that gave us the victory,” the legend was quoted.advertisementLegend has it that Adolf Hitler was so impressed by Dhyan Chand’s wizardry with the stick in the 1936 Berlin Olympics that he offered him German citizenship and the post of Colonel in his army, which the Indian declined with a smile.Dhyan Chand’s younger brother Roop Singh was also a legendary hockey player and was part of the 1932 and 1936 Olympic gold-medal winning teams. Roop Singh and Dhyan Chand were labelled the hockey twins after the duo scored a staggering 24 out of the 35 goals in the 1932 Los Angeles Games against Japan and USA with the younger brother scoring 13 goals while Chand scored 11.