Possible vCJD case in UK may signal more to come

first_img Though a single case can’t be the basis for connecting a novel PrPSc type to BSE, “it will be important to see whether other similar cases occur in the United Kingdom and other BSE-exposed countries,” the researchers wrote. The researchers, who reported their findings in the December 2007 issue of Archives of Neurology, found that the 39-year-old woman carried the VV (valine-homozygous) version of the prion protein gene (PRNP), a type previously thought to confer protection against vCJD. The authors wrote that it wasn’t clear if the PrPSc typing points to a BSE cause of the patient’s illness or if the finding represents another form of sporadic CJD. In early 1999 the patient described started having visual symptoms, followed by a host of other neurological problems, such as memory and gait impairments, according to the report. Polymerase chain reaction testing revealed that the patient had the VV variant of the PRNP gene. The patient died 14 months later. Jun 12, 2006, CIDRAP News story “Study implies broader risk for vCJD in UK” Will Hueston, DVM, PhD, director of the University of Minnesota Center for Animal Health and Food Safety in St. Paul, told CIDRAP News that it’s too soon to say whether the DNA findings from the woman are associated with BSE. “I think that neurologists are probably attempting to be more cautious,” he said. “This is most likely not BSE, but they [the researchers] want to be very clear that similar cases should be thoroughly evaluated.” UK National CJD Surveillance Unit surveillance statistics Simon Mead, the study’s lead author, said the findings shouldn’t cause alarm, according to a Jan 5 New Scientist report. “The final conclusion remains open. It is waving the flag for neurologists to watch for other cases,” said Mead, who is at the Medical Research Council Prion Unit at University College London. Mead S, Joiner S, Desbruslais S, et al. Creutzfeldt-Jakob disease, prion protein gene codon 129VV, and a novel PrPSc type in a young British woman. Arch Neurol 2007 Dec;64(12):1780-74 [Abstract] See also: Past research has linked vCJD to eating meat products contaminated with brain and spinal cord material from cattle infected with bovine spongiform encephalopathy (BSE), or mad cow disease. Normal prion proteins in the brain are corrupted after contact with the BSE agent, eventually causing death in both cattle and humans. BSE, vCJD, and sporadic CJD—a rare disease of unknown cause that closely resembles vCJD—are all prion diseases, also known as transmissible spongiform encephalopathies. The results of the study could also signify another variant of CJD, which is already known to occur in various forms, “but they don’t know what box to put it in,” said Hueston, adding that classifying prion disease types is often difficult. The authors of the 2006 study suggested their findings might mean that people who are infected with vCJD and have a VV type may have a prolonged incubation period, during which the disease could spread either via blood donations or from contaminated surgical instruments used on the individuals during the asymptomatic phase of the illness. In 2006, another group of British researchers analyzed DNA from three surgical samples that had previously tested positive in immunohistochemical studies of vCJD prevalence in the UK (though the patients had no clinical signs of the disease). Genotype analysis of the patients’ PRNP at codon 129 found that two of the samples were of the VV type, providing the first evidence that patients from this subgroup could be infected. (DNA could not be extracted from the third sample.) Previously, people who carried at least one copy of the V variant of PRNP were thought to have no risk of contracting vCJD. Studies in transgenic mice are under way to explore transmission characteristics related to the woman’s case, according to the report. Cases of vCJD began surfacing in the United Kingdom in 1996, in the wake of a BSE epidemic in cattle. According to the most recent update from the National CJD Surveillance Unit (NCJDSU) based at the Western General Hospital in Edinburgh, Scotland, the number of patients in the UK who have died of confirmed or probable vCJD stands at 163. Until the case described, all vCJD patients who had been tested had the MM (methionine-homozygous) version of PRNP. Jan 9, 2008 (CIDRAP News) – A British woman who died of a brain disease suggestive of variant Creutzfeld-Jacob disease (vCJD) had a genetic marker not seen in any previous vCJD patients, raising the possibility that her illness represented a new form of the disease that could signal a new wave of infections, according to a recent research report. Mead told New Scientist that patterns of prion disease seem to vary among people depending on the prion gene variant they have, and incubation period could be one aspect in which the variants differ. Experts have said CJD is known to have a long incubation period, perhaps as long as 50 years. Brain autopsy findings included severe gray- and white-matter degeneration and extensive prion protein deposits in the cortex and white matter, which the authors wrote is atypical for sporadic CJD. Molecular analysis of the pathologic prion protein (PrPSc) from the woman’s cerebellar tissue showed a novel type of PrPSc that was similar in some, but not all, respects to type 4, which is seen in vCJD.last_img read more

#AskMeFirst: The left’s shameful response to Laura…

first_imgWriting by Renee Bloghttps://reneejg.net/2017/02/24/askmefirst/….Cue the liberal backlash. Journalists on the left are completely ignoring the implications to girls’ and women’s safety of opening up female-only spaces on the basis of identity politics, being too busy scrambling to profess their “love” for trans people and hatred of “bigotry” to think about girls. They are so rushed, in fact, they can’t even stop to define the terms of their own arguments. The Herald‘s Lizzie Marvelly cannot cough up a definition of a “girl” to back up her choice to ride roughshod over a young woman’s legitimate concerns about her rights to consent, privacy, safety and speech.Commentators like Alison Mau and Marvelly have dismissed Laura herself as “exploited” by Family First, in order to sidestep consideration of the concerns she raises. Auckland University academic equity leader Lexie Matheson even bluffs that this “exploitation” actually “worries” him.… Women are increasingly prevented from discussing the root causes of epidemics that affect us, like eating disorders and sexual abuse – because doing so involves looking at the nature of gender as a hierarchical system that men impose on women, on the basis of sex. Even saying this is now considered “transphobic”, because “transwomen are women!”… To see Laura’s legitimate concerns dismissed in this condescending manner is nauseating. Given these sorts of reactions, it is also no wonder that women and radical feminists are finding themselves increasingly accepting support from right wing groups.… So if the right supports girls and women like Laura to ask questions pertinent to our safety, while liberals hound and bully them for it – those same liberals should be prepared. When more and more women start making political swings to the right, seeing no other options to make themselves heard – liberals will only have themselves to blame.READ THE FULL EXCELLENT POST: https://reneejg.net/2017/02/24/askmefirst/last_img read more

BKFC: Iranian Hulk is set to make his debut in Bare Knuckle Fighting Championship in 2020

first_imgAlso Read- Charles Oliveira Brags About Winning Future UFC Fight With Khabib NurmagomedovAlso Read- UFC: Nate Diaz Roasted By Former British Champion With Mike Tyson Reference Post UFC 244 Raj Sarkar Also Read- UFC Nate Diaz: Fighter’s Salary, Net Worth And Next UFC FightBKFC: Iranian Hulk in social mediaSajad Gharibi a.k.a ‘Iranian Hulk’ gained a lot of popularity on his social media handle. The giant-sized human stunned netizens with his Instagram photos and workout visuals on YouTube. Take a look at his pictures before seeing him inside the cage. LIVE TV SUBSCRIBE TO US First Published: 19th November, 2019 20:30 IST Written By ” He’s literally our biggest signing we’ve ever had. But he’s going to make his way over to Bare Knuckle Fighting Championship, he’s gonna make a home here, and we expect really, really big things from ‘The Iranian Hulk.” said Bare Knuckle Fighting Championship President in an interview Last Updated: 19th November, 2019 20:30 IST BKFC: Iranian Hulk Is Set To Make His Debut In Bare Knuckle Fighting Championship In 2020 Sajad Gharib a.k.a The Iranian Hulk has been signed by the Bare Knuckle Fighting Championship and he is set to debut in early 2020. Know how it happened. COMMENT WATCH US LIVE It is a “Big Man’s Show” and Bare Knuckle Fighting took it really seriously by signing the Iranian Hulk in their roster. Sajad Gharibi is a powerlifter from Ahwaz, Iran who has gained popularity on social media due to his massive physique. The 27-year-old is 6’2” in height with a weight of 175 kilos. After being a successful powerlifter, the ‘Iranian Hulk’ has made his move to combat sports by signing a deal with one of the largest emerging combat sports promotion – Bare Knuckle Fighting Championship.Also Read- UFC: Ex-fighter Jason Knight Embarrassed Over Old Bathroom Brawl Video Going ViralBare Knuckle Fighting Championship: Iranian Hulk’s BKFC DebutThe gigantic man will be making his debut in early 2020. It is scary to think that Sajad Gharibi is going to throw punches without any gloves. Bare Knuckle Fighting Championship President David Feldman thinks that the ‘Iranian Hulk’ is a massive signing for his promotion and believes that he is going to make it big in BKFC. Sajad Gharibi has never fought in a combat sport but he is popular and he will definitely garner a lot of eyes for his BKFC fight. BKFC is planning to host a show titled “USA vs Iran: World WAR III” and President Feldman believes that the ‘Iranian Hulk’ might make his debut on that card. BKFC is yet to announce a date for Iranian Hulk’s debut but it is expected to be in early 2020. FOLLOW US WE RECOMMEND 9 months ago UFC: Ex-fighter Jason Knight embarrassed over old bathroom brawl video going virallast_img read more

Local GAA action

first_imgThere’s plenty of local GAA action on around the county this weekend.First up this afternoon is the meeting of near neighbours Arravele Rovers and Galtee Rovers in the West Senior Football Final.Both have to win west to stay in the county, however Galtee Rovers have the upper hand, having beaten Arravale in the recent O’Donoghue Cup final. Photo ©Stephen Gleeson The game throws in in Annacarthy at 3 o’clock, and Arravale Selector Tommy Twoomey says they’ll have to be ready for the Galtee’s challenge…Before that game, at 1.30, Rockwell Rovers meet Clonoulty Rossmore in the intermediate decider.Then this evening at half 5, Killenaule meet Carrick Swans in the South Senior Hurling Final.Swans are the most decorated south tipp hurling club with 22 south titles to their name.However, Killenaule have 21 titles, and a win this evening would see them level with Swans.That game is on in Fethard.Also down for decision this evening is the North Senior hurling final which throws in at 6pm in NenaghNenagh Eire Og face Borrisoleigh, in what is expected to be a pulsating game.Borrisoleigh Coach Johnny Kelly is a Portumna man, and with the Galway in the All Ireland Final tomorrow, he says his sole focus is on the North game…Finally this evening sees the Mid Tipp Intermediate hurling final at 6 o clock in Holycross.It sees Thurles Sarsfields up against Gortnahoe Glengoole.last_img read more